RIPK1 inhibitor 22b（RIPK1-IN-7） (C007B-585049)

Catalog No.: C007B-585049
Manufacturer No.: R613198-50mg
Manufacturer Name: Aladdin Scientific
Quantity: 1
Unit of Measure: EA

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Description
Specifications

RIPK1 inhibitor 22b is a potent and selective inhibitor of RIPK1(Kd of 4 nM and an enzymatic IC50 of 11 nM),andexhibits excellent antimetastasis activity in the experimental B16 melanoma lung metastasis model.Â Â In vitro activityIn the TSZ-induced HT29 cell necroptosis model, RIPK1 inhibitor 22b shows potent cell protection effect (EC50 of 2nM). RIPK1 inhibitor 22b displays considerable activity against several other kinases(Flt4, TrkA, TrkB, TrkC, Axl, HRI, Mer, and MAP4K5 with IC50s of 20, 26, 8, 7, 35, 26, 29, and 27 nM, respectively).

Specifictaions: Moligandâ„¢, â‰¥98%

MDL Number: C25H22F3N5O2

Molecular Formula: 481.47

PubChem CID: 137321158

Isomeric SMILES: CCN1C=C(C2=C(N=CN=C21)N)C3=CC4=C(C=C3)N(CC4)C(=O)CC5=CC(=CC=C5)OC(F)(F)F

UPC:: 51142501
Condition:: New
HazmatClass:: No
WeightUOM:: LB
MPN:: R613198-50mg
CAS:: 2300982-44-7
Product Size:: 50mg

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