RIPK1-IN-7 (C007B-415671)

RIPK1-IN-7 is a potent and selective RIPK1 inhibitor with a K d of 4 nM and an enzymatic IC 50 of 11 nM. RIPK1-IN-7 exhibits excellent antimetastasis activity in the experimental B16 melanoma lung metastasis modelIn VitroRIPK1-IN-7 shows potent cell protection effect in the TSZ-induced HT29 cell necroptosis model with an EC 50 of 2nM. RIPK1-IN-7 displays considerable activity against several other kinases, such as Flt4, TrkA, TrkB, TrkC, Axl, HRI, Mer, and MAP4K5 with IC 50 s of 20, 26, 8, 7, 35, 26, 29, and 27 nM, respectively. MCE has not independently confirmed the accuracy of these methods. They are for reference only.Form:SolidIC50& Target:IC50: 11 nM (RIPK1), Kd: 4 nM (RIPK1).

Specifications and Purity: ≥98%

Molecular Formula: C25H22F3N5O2

Molecular Weight: 481.5

PubChem CID: 137321158

Isomeric SMILES: CCN1C=C(C2=C(N=CN=C21)N)C3=CC4=C(C=C3)N(CC4)C(=O)CC5=CC(=CC=C5)OC(F)(F)F