RIPA-56 (C007B-258929)

InformationRIPA-56 RIPA-56 is a highly-potent, selective, and metabolically stable RIP1 (RIPK1) inhibitor.TargetsRIP1 (Cell-free) 13 nMIn vitroRIPA-56 shows efficient inhibition of RIP1 kinase activity, with an IC50 of 13 nM. It showed no inhibition of RIP3 kinase activity at a 10 µM concentration. RIPA-56 does not inhibit IDO activity at a concentration of 200 µM, which represents an estimated 10,000-fold selectivity window based on the RIP1 ADP-Glo activity of 13 nM.In vivoRIPA-56 has an impressive PK profile in mice, with a 3.1 h half-life, 22% oral bioavailability (PO), and 100% bioavailability from intraperitoneal injection (IP). RIPA-56 has great ability in transporting across blood brain barrier. In the SIRS mice disease model, RIPA-56 efficiently reduced tumor necrosis factor alpha (TNFα)-induced mortality and multi-organ damage.

Specifications and Purity: 10mM in DMSO

Molecular Formula: C13H19NO2

Molecular Weight: 221.3

PubChem CID: 121439991

Isomeric SMILES: CCC(C)(C)C(=O)N(CC1=CC=CC=C1)O