RIP1 kinase inhibitor 1 (C007B-416067)

Catalog No.: C007B-416067
Manufacturer No.: R651327-10mg
Manufacturer Name: Aladdin Scientific
Quantity: 1
Unit of Measure: EA

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Description
Specifications

RIP1 kinase inhibitor 1 (compound 22) is a highly potent, orally available, and brain-penetrating RIP1 kinase inhibitor ( pK i =9.04)In VitroRIP1 kinase inhibitor 1 (compound 22) strongly suppresses necroptotic cell death and phosphorylation of MLKL(pMLKL) in human colorectal adenocarcinoma HT-29 cells (nectoptosis, IC 50 =2 nM; pMLKL, IC 50 =1.3 nM) as well as mouse L-cells NCTC 929 (nectoptosis, IC 50 =15 nM; pMLKL, IC 50 =2.7 nM). MCE has not independently confirmed the accuracy of these methods. They are for reference only.Form:SolidIC50& Target:pKi: 9.04 (RIP1 kinase).

Specifications and Purity: ≥99%

Molecular Formula: C24H20ClN5O3

Molecular Weight: 461.90

UPC:: 51111717
Condition:: New
HazmatClass:: No
WeightUOM:: LB
MPN:: R651327-10mg
CAS:: 2095515-38-9
Product Size:: 10mg

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