Ribociclib (LEE011)

Catalog No.: C007B-258354
Manufacturer No.: R407791-1ml
Manufacturer Name: Aladdin Scientific
Quantity: 1
Unit of Measure: EA

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Description
Specifications

InformationRibociclib (LEE011) Ribociclib (LEE011) is an orally available, and highly specific inhibitor of CDK4 and CDK6 with IC50 of 10 nM and 39 nM. Phase 3.In vitroLEE011, as dual CDK4/CDK6 inhibitor, significantly inhibits the growth of 12 of 17 neuroblastoma cell lines with mean IC50 of 307 nM. The growth inhibition of neuroblastoma cell lines is primarily cytostatic and is mediated by a G1 cell-cycle arrest and cellular senescence. [1]In vivoLEE011 (200 mg/kg daily, p.o.) significantly causes tumor growth delay in mice harboring the BE2C or 1643 xenografts with no weight loss or other signs of toxicity.Cell Datacell lines：Concentrations：10 μMIncubation Time：~100 hoursPowder Purity:≥99%.

Specifications and Purity: 10mM in DMSO

Molecular Formula: C23H30N8O

Molecular Weight: 434.54

UPC:: 12141723
Condition:: New
HazmatClass:: No
WeightUOM:: LB
MPN:: R407791-1ml
CAS:: 1211441-98-3
Product Size:: 1ml

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