Recombinant Human UCH-L1/PGP9.5 Protein (C09-1573-718)

Purity: ≥95%, by SDS-PAGE visualized with Coomassie® Blue Staining.Description:Deubiquitination is a critical regulatory process in the ubiquitin-proteasome pathway. Ubiquitin C-terminal hydrolases (UCHs) are a family of cysteine proteases that catalyze the hydrolysis of a peptide bond at the C-terminal glycine of ubiquitin. Members of the UCH family have been implicated in a number of human diseases, including neurodegenerative diseases and cancers. Mutations of the UCH-L1 gene and alterations of the protein activity have been found to be associated with several neurodegenerative disorders, including Parkinson’s, Huntington’s and Alzheimer’s diseases. It is also implicated in cancer tumorigenesis, including lung, breast, liver, kidney, colorectal and ovarian cancers. UCH-L1 is thought to be a tumor suppressor and biomarker for hepatocellular carcinoma and other digestive tumors.

Specifications and Purity: Carrier Free, ≥95%(SDS-PAGE)