Recombinant Human Serpin E1/PAI-1 Protein (C09-1573-685)

As a member of the Serpin superfamily of serine protease inhibitors, Serpin E1/PAI 1 is the principal inhibitor of urokinase type plasminogen activator (uPA) and tissue type PA. As important regulators of extracellular matrix remodeling, uPA and PAI 1 play a major role in many processes such as angiogenesis, tumor invasion, and obesity. For example, uPA and PAI-1 are the only tumor prognostic factors validated at the highest level of evidence with regard to their clinical utility in breast cancer. The human PAI-1 is initially synthesized as 402 amino acid precursor with an N terminal signal peptide. PAI 1 may exist in one of two possible conformations, designated as active or latent. The purified rhPAI 1 is active against rhuPA. The heterogeneity at the N terminus of the purified rhPAI 1 has been observed before for both the recombinant and native proteins.

Specifications and Purity: ActiBioPure™, Bioactive, Animal Free, Carrier Free, ≥95%(SDS-PAGE)