RAPTINAL (C005B-311682)

Catalog No.: C005B-311682
Manufacturer No.: SML1745-5MG
Manufacturer Name: Sigma-Aldrich
Quantity: 5
Unit of Measure: MG

Application Raptinal showed complete cytochrome c release within 30 minutes and caspase-3 activation within one hour of exposure (10 μ:M). Despite its general cytotoxicity in both cancer and non-cancer cell cultures (Cell death induction

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Description
Specifications

Application

Raptinal showed complete cytochrome c release within 30 minutes and caspase-3 activation within one hour of exposure (10 μM). Despite its general cytotoxicity in both cancer and non-cancer cell cultures (Cell death induction EC50 = 0.6-3.4 μM in 24 hr), no hematologic toxicity was observed 7 days following single 60 mg/kg i.v. dosing in mice. Studies show that daily i.p. injection (20 mg/kg) is efficacious in suppressing murine B16-F10 melanoma and 4T1 breast cancer expansion in vivo (by ~60% and 50% in 6 days, respectively).

Biochem/physiol Actions

Raptinal is a cell-permeable bifluorene-dicarbaldehyde compound that acts as a rapid activator of mitochondrial pathway-mediated intrinsic apoptosis.

UPC:: 10161526
Condition:: New
HazmatClass:: No
MPN:: SML1745-5MG
CAS:: 1176-09-6

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