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pumosetrag hydrochloride (c09-1165-258)

Pumosetrag Hydrochloride (C007B-386786)

Catalog No.
C007B-386786
Manufacturer No.
P655825-1ml
Manufacturer Name
Aladdin Scientific
Quantity
1
Unit of Measure
EA

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Pumosetrag Hydrochloride (MKC-733: DDP-733) is an orally available 5-HT3 partial agonist developed for the treatment of irritable bowel syndrome and gastroesophageal reflux disease.In VivoPumosetrag displays both regional and species specificities.

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Pumosetrag Hydrochloride (MKC-733; DDP-733) is an orally available 5-HT3 partial agonist developed for the treatment of irritable bowel syndrome and gastroesophageal reflux disease.In VivoPumosetrag displays both regional and species specificities. Pumosetrag has a lower efficacy than 5-HT in the rat jejunum, ileum and distal colon; however, it has similar efficacy and potency to 5-HT in the rat proximal colon. The activity profile of Pumosetrag is different in the guinea pig intestine where it exhibits greater potency and efficacy than 5-HT in all regions. Pumosetrag shows little to no response in the regions of the mouse intestine. Responses to Pumosetrag in the rat and guinea pig tissues are inhibited by ondansetron, confirming its action on 5-HT(3) receptors . Pumosetrag delays liquid gastric emptying in association with relaxation of the proximal stomach, stimulates fasting antroduodenal migrating motor complex activity and accelerates small intestinal transit. MCE has not independently confirmed the accuracy of these methods. They are for reference only.IC50& Target:5-HT 3 Receptor.

Specifications and Purity: 10mM in DMSO

Molecular Formula: C15H18ClN3O2S

Molecular Weight: 339.84

UPC:
51191501
Condition:
New
HazmatClass:
No
WeightUOM:
LB
MPN:
P655825-1ml
CAS:
194093-42-0
Product Size:
1ml

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