PSB-12062 is a potent and selective P2X4 antagonist with an IC 50 of 1.38 μM for human P2X4.In VitroPSB-12062 shows similar potency in human, rat, and mouse species. PSB-12062 shows to be allosteric in nature with a 35-fold selectivity toward P2X4 versus P2X1, P2X2, P2X3, and P2X7. However, PSB-12062 is unable to completely block ATP-induced P2X4-mediated calcium influx even when used at high concentrations (>30 μM). MCE has not independently confirmed the accuracy of these methods. They are for reference only.IC50& Target:IC50: 1.38 μM (human P2X4), 92.8 nM (rat P2X4), 1.76 μM (mouse P2X4).
Specifications and Purity: 10mM in DMSO
Molecular Formula: C19H15NO3S
Molecular Weight: 337.39
- UPC:
- 41103025
- Condition:
- New
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- P654727-1ml
- CAS:
- 55476-47-6
- Product Size:
- 1ml
akash.verma@cenmed.com
(732) 447-1115





