PGE3 is formed via the COX metabolism of EPA. In human ocular tissue, it comprises 2.4% of the COX products formed. When applied to the eyes of a rabbit, a 1 µg dose of PGE3 decreases IOP from 21 mmHg to about 17 mmHg.
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PGE3 is formed via the COX metabolism of EPA. In human ocular tissue, it comprises 2.4% of the COX products formed. When applied to the eyes of a rabbit, a 1 µg dose of PGE3 decreases IOP from 21 mmHg to about 17 mmHg.
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