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probenecid (c15-1873-171)

PROBENECID (C005B-438047)

Catalog No.
C005B-438047
Manufacturer No.
P8761-100G
Manufacturer Name
Sigma-Aldrich
Quantity
100
Unit of Measure
GM

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Application Probenecid has been used: as a component of phenol red free Hank′:s buffer for Intracellular Ca 2+ -mobilization assay as a component of calcium sensitive dye for calcium mobilization Studies as a supplement in Hank′:s

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Application

Probenecid has been used:

  • as a component of phenol red free Hank′s buffer for Intracellular Ca2+-mobilization assay
  • as a component of calcium sensitive dye for calcium mobilization Studies
  • as a supplement in Hank′s balanced salt solution (HBSS) assay buffer

Useful as an inhibitor of the organic anion transporter, MRP.

Biochem/physiol Actions

Probenecid is a uricosuric agent, which increases uric acid removal in the urine and reduces urate reuptake. It also reduces the renal tubular excretion of many other drugs and increases their plasma concentration. The inhibitory action of probenecid is mediated by organic anion transporters. It is found useful for the treatment of gout. Probenecid is responsible for the rise in the levels of neurochemicals in the brain by preventing its movement from choroid plexus and parenchyma cells into plasma.

Features and Benefits

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound was developed by Merck & Co., Inc., Kenilworth, NJ, U.S.. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

UPC:
41105324
Condition:
New
HazmatClass:
No
MPN:
P8761-100G
CAS:
57-66-9

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