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PRL-3 INHIBITOR I

Catalog No.
C005B-440883
Manufacturer No.
P0108-5MG
Manufacturer Name
Sigma-Aldrich
Quantity
5
Unit of Measure
MG

Application PRL-3 Inhibitor I has been used as an inhibitor of phosphatase of regenerating liver-3 (PRL-3): to test its effect on classical Hodgkin lymphoma cell survival in the human umbilical vein endothelial cells tube formation assay to

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Application

PRL-3 Inhibitor I has been used as an inhibitor of phosphatase of regenerating liver-3 (PRL-3):

  • to test its effect on classical Hodgkin lymphoma cell survival
  • in the human umbilical vein endothelial cells tube formation assay
  • to test its effect on the migration of neural crest cells

Biochem/physiol Actions

PRL-3 Inhibitor I is a rhodanine derivative with an IC50 value of 0.9 μM against phosphatase of regenerating liver-3 (PRL-3), a nonclassical protein tyrosine phosphatase that has recently been shown to be involved in cancer metastasis. PRL-3 Inhibitor I reduced the invasiveness of B16F10 melanoma cells in a cell based assay.

Features and Benefits

This compound is featured on the Phosphoprotein Phosphatases (Tyrosine) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

UPC:
51142508
Condition:
New
HazmatClass:
No
MPN:
P0108-5MG
CAS:
893449-38-2

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