Application
PRL-3 Inhibitor I has been used as an inhibitor of phosphatase of regenerating liver-3 (PRL-3):
- to test its effect on classical Hodgkin lymphoma cell survival
- in the human umbilical vein endothelial cells tube formation assay
- to test its effect on the migration of neural crest cells
Biochem/physiol Actions
PRL-3 Inhibitor I is a rhodanine derivative with an IC50 value of 0.9 μM against phosphatase of regenerating liver-3 (PRL-3), a nonclassical protein tyrosine phosphatase that has recently been shown to be involved in cancer metastasis. PRL-3 Inhibitor I reduced the invasiveness of B16F10 melanoma cells in a cell based assay.
Features and Benefits
This compound is featured on the Phosphoprotein Phosphatases (Tyrosine) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
- UPC:
- 51142508
- Condition:
- New
- HazmatClass:
- No
- MPN:
- P0108-5MG
- CAS:
- 893449-38-2
akash.verma@cenmed.com
(732) 447-1115





