PRIMA-1 (C005B-440916)

Catalog No.: C005B-440916
Manufacturer No.: P0069-5MG
Manufacturer Name: Sigma-Aldrich
Quantity: 5
Unit of Measure: MG

General description P53-dependent reactivation and induction of massive apoptosis (PRIMA-1) is a low molecular weight compound and has a role in cancer therapy. PRIMA-1 stimulates cytotoxic effects in human cancer cells.

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Description
Specifications

General description

P53-dependent reactivation and induction of massive apoptosis (PRIMA-1) is a low molecular weight compound and has a role in cancer therapy. PRIMA-1 stimulates cytotoxic effects in human cancer cells. It induces eryptosis.

Biochem/physiol Actions

PRIMA-1 is a selective re-activator of mutant p53 activity in tumor cells, and an inducer of apoptosis and inhibitor of growth of human tumors with mutant p53. Mutations in the tumor suppressor p53 take place in >50% tumor cells. PRIMA-1 selectively restores sequence-specific DNA binding and transactivational activity to mutant p53 proteins at μM concentrations. PRIMA-1 works as a re-activator of the apoptotic function of mutant p53 via conformational modulation of function-specific epitopes.

UPC:: 10161646
Condition:: New
HazmatClass:: No
MPN:: P0069-5MG
CAS:: 5608-24-2

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