PR-619 (C005B-313385)

Catalog No.: C005B-313385
Manufacturer No.: SML0430-5MG
Manufacturer Name: Sigma-Aldrich
Quantity: 5
Unit of Measure: MG

Application PR-619 has been used: as a component of lysis buffer and also as a deubiquitinase inhibitor to treat proteins derived from SILAC-labeled Jurkat cells as a pan-deubiquitinase inhibitor to study its effect on adenoassociated virus

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Description
Specifications

Application

PR-619 has been used:

as a component of lysis buffer and also as a deubiquitinase inhibitor to treat proteins derived from SILAC-labeled Jurkat cells
as a pan-deubiquitinase inhibitor to study its effect on adenoassociated virus (AAV) transduction
in radioimmunoprecipitation assay buffer (RIPA) buffer used for ubiquitination assays

Biochem/physiol Actions

PR-619 is a cell permeable broad spectrum deubiquitylating enzymes (DBUs) inhibitor. PR-619 induces the accumulation of polyubiquitylated proteins in cells without directly affecting proteasome activity.

UPC:: 41113403
Condition:: New
HazmatClass:: No
MPN:: SML0430-5MG
CAS:: 2645-32-1

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