Polymyxin B sulfate (C007B-399424)

Chemical structure: peptidePolymyxin B sulfate is a strongly cationic cyclic polypeptide antibiotic that is derived from fermentation of Bacilus polymyxa. It is a mixture of B1 and B2 sulfate. The product has been used clinically to treat infections of the urinary tract, meninges and blood stream caused by susceptible strains of Pseudomonas aeruginosa†. It also has uses studying multidrug-resistant pathogens††, as an immobilized agent for removal of endotoxins, and to induce pore formation in the membranes of cortex cells from excised sorghum roots.Polymyxin B sulfate salt has been used:•  in human aortic endothelial cells (HAEC) cell culture to exclude potential endotoxin contamination in recombinant adiponectin•  in the analysis of the isolates•  in endotoxin-neutralizing activity of α-amylase (AmyI-1)-18 (LAL assay).

Specifications and Purity: USP

MDL Number: MFCD00131991

Molecular Formula: C56H100N16O17S

Molecular Weight: 1301.6

PubChem CID: 5702105

Isomeric SMILES: CCC(C)CCCCC(=O)NC(CCN)C(=O)NC(C(C)O)C(=O)NC(CCN)C(=O)NC1CCNC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC1=O)CCN)CC2=CC=CC=C2)CC(C)C)CCN)CCN)C(C)O.OS(=O)(=O)O

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