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poly-l-histidine (c15-1872-928)

POLY-L-HISTIDINE MOL WT 5000-15000 (C005B-437846)

Catalog No.
C005B-437846
Manufacturer No.
P9386-100MG
Manufacturer Name
Sigma-Aldrich
Quantity
100
Unit of Measure
MG

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General description Poly- L -histidine is an amphoteric compound. The imidazole ring in its structure enables protonation−:deprotonation.

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General description

Poly-L-histidine is an amphoteric compound. The imidazole ring in its structure enables protonation−deprotonation.

Application

Poly-L-histidine has been used:

  • as a polycation for the dispersion of multi-wall carbon nanotubes (MWCNTs)
  • as a polyionic compound to investigate its ability to rupture extracellular enveloped virus membrane
  • in screening its anti-prion activity in cell based and in vivo anti-prion assay

Biochem/physiol Actions

Poly-L-histidine (Phis) copolymers are biocompatible, pH responsive and are less toxic. It exhibits endolysosomal escape funcationality. The copolymer of Phis with poly(ethylene glycol)−poly(d,l-lactide) (PEG-PLA) is effective in delivering doxorubicin. pH sensitive poly(l-histidine) copolymer micelles have application in delivering anticancer drugs in acidic microenvironment.

Analysis Note

Molecular weight by MALLS.

Other Notes

For additional technical information on polyamino acids please visit the Polyamino acid FAQ resource.

UPC:
51102722
Condition:
New
HazmatClass:
No
MPN:
P9386-100MG
CAS:
26062-48-6

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