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pilsicainide hydrochloride (c15-1876-489)

PILSICAINIDE HYDROCHLORIDE (C005B-440957)

Catalog No.
C005B-440957
Manufacturer No.
P0026-50MG
Manufacturer Name
Sigma-Aldrich
Quantity
50
Unit of Measure
MG

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Application Pilsicainide hydrochloride has been used as a sodium channel blocker: to study its effects on electrophysiological parameters in guinea pig pulmonary vein preparation to study its effects on Ca 2+  :release and arrhythmic

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Application

Pilsicainide hydrochloride has been used as a sodium channel blocker:

  • to study its effects on electrophysiological parameters in guinea pig pulmonary vein preparation
  • to study its effects on Ca2+ release and arrhythmic events in Andersen-Tawil syndrome induced pluripotent stem cells (ATS-iPSC)-derived cardiomyocytes
  • to study its electrophysiological effects on the guinea pig atrium

Biochem/physiol Actions

Pilsicainide hydrochloride is a pure sodium channel blocker and an open channel blocker of Na+1 channels. Pilsicainide was defined as a pure sodium channel blocker. The compound is classified as a class Ic antiarrhythmic drug, and was originally developed in Japan. Similar to Lidocaine, Pilsicainide binds to open channels, but slowly. Pilsicainide is capable of selectively blocking the late currents in the mutant Na(+) channels that show dominant abnormal burst openings such as in δKPQ mutants. The compound is used to induce Brugada syndrome (BS) in animal models.

Features and Benefits

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

UPC:
51191501
Condition:
New
HazmatClass:
Yes
MPN:
P0026-50MG

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