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phloretin (c15-1873-430)

PHLORETIN (C005B-438279)

Catalog No.
C005B-438279
Manufacturer No.
P7912-250MG
Manufacturer Name
Sigma-Aldrich
Quantity
250
Unit of Measure
MG

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General description Phloretin a polar dye belongs to the class of dihydrochalcones. Major polyphenol found in apple: aglycone of phloridzin.

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General description

Phloretin a polar dye belongs to the class of dihydrochalcones.

Major polyphenol found in apple; aglycone of phloridzin.

Application

Phloretin has been used:

  • to study its effect on the 2-[N-(7-Nitrobenz-2-oxa-1,3-diazol-4-yl)amino]-2-deoxy-d-glucose (2-NBDG) and 2-[N-(7-Nitrobenz-2-oxa-1,3-diazol-4-yl)amino]-2-deoxy-l-glucose (2-NBDLG) uptake
  • to incubate microvesicles in order to inhibit GLUT1 (glucose transporter 1)-mediated transport in radioactive ligand up-take assay
  • as a component of KRH buffer to stop glucose uptake by trophoblast cells in vitro

Biochem/physiol Actions

Blocks L-type Ca2+ channels; activates Ca2+-activated K+ channels in amphibian myelinated nerve fibers. Monocarboxylate transporter inhibitor.

Phloretin is known to decrease interfacial dipole potential of lipid bilayer. Phloretin possess antitumor action by preventing protein kinase C (PKC) activity and stimulating programmed cell death. It is found to inhibit the transport functions of GLUTs (glucose transporter) and aquaporins.

Reacts with vic-dicarbonyl compounds such as glyoxal and methylglyoxal, preventing cytotoxic conjugation with biological macromolecules.

UPC:
51111907
Condition:
New
HazmatClass:
No
MPN:
P7912-250MG
CAS:
60-82-2

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