akash.verma@cenmed.com
(732) 447-1115
PHD-1-IN-1 is an orally active and potent HIF prolylhydroxylase domain-1 (PHD-1) inhibitor with an IC 50 of 0.034 μM. PHD-1-IN-1 has a unique monodentate binding interaction with the active site Fe 2+ ion and induces the formation of an “Arg367-out” pocketIn VivoPHD-1-IN-1 (compound 17; 3 mg/kg of p.o. or 0.5 mg/kg of i.v.) has a C max of 0.8 μM, a AUC of 176 ng•h/mL, K p,uu of 1.11 and B/P of 0.95 . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Male C57BL6 mice Dosage: 3 mg/kg (p.o.) or 0.5 mg/kg (i.v.) (Pharmacokinetic Analysis) Administration: PO or IV Result: Had a C max of 0.8 μM, a AUC of 176 ng•h/mL, K p,uu of 1.11 and B/P of 0.95.Form:SolidIC50& Target:IC50: 0.034 μM (PHD-1).
Specifications and Purity: ≥99%
Molecular Formula: C13H8N4
Molecular Weight: 220.23
- UPC:
- 85131701
- Condition:
- New
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- P646307-50mg
- CAS:
- 2009343-14-8
- Product Size:
- 50mg
