PF 6274484 is a high affinity, irreversible covalent inhibitor of EGFR kinase with Ki of 0.14 nM. PF 6274484 inhibits the autophosphorylation of wild-type EGFR in A549 cells and EGFRL858R/T790M in H1975 cells with IC50 of 5.8 nM and 6.6 nM, respectively.
Specifications and Purity: ≥98%(HPLC)
Molecular Formula: C18H14ClFN4O2
Molecular Weight: 372.78
PubChem CID: 74766099
Isomeric SMILES: COC1=C(C=C2C(=C1)N=CN=C2NC3=CC(=C(C=C3)F)Cl)NC(=O)C=C
Related Documents: https://aladdin-for-icloud-store.oss-cn-hangzhou.aliyuncs.com/aladdinsci/pdp/sds/1/P288199-SCI_a5b349249c54fec820a4abae61de68df.pdf
- UPC:
- 12141723
- Condition:
- New
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- P288199-250mg
- CAS:
- 1035638-91-5
- Product Size:
- 250mg
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