PF-06843195 (C005B-309347)

Catalog No.: C005B-309347
Manufacturer No.: SML3217-25MG
Manufacturer Name: Sigma-Aldrich
Quantity: 1
Unit of Measure: EA

Biochem/physiol Actions PF-06843195 is a potent and PI3K-alpha subtype-selective phosphoinositide 3-kinase (PI3K) inhibitor (rat PI3K Ki = 2 nM/β:, <:18 nM/α:, <:280 nM/δ:) that inhibits cellular PI3Kα: activity at a higher

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Description
Specifications

Biochem/physiol Actions

PF-06843195 is a potent and PI3K-alpha subtype-selective phosphoinositide 3-kinase (PI3K) inhibitor (rat PI3K Ki = 2 nM/β, <18 nM/α, <280 nM/δ) that inhibits cellular PI3Kα activity at a higher potency over that of PI3Kδ/β and mTOR (AKT pT308 IC50 = 18/160/360 nM in rat PI3Kα/δ/β Rat1 lines; p70S6K pT389 IC50 = 1.5 μM in Rat1 myristoylated PI3K line). PF-06843195 is more potent against cellular AKT pT308 (MCF7/T47D IC50 = 7.8/8.7 nM) and proliferation (MCF7/T47D = 62/32 nM) than alpelisib (BYL719) in cultures.

Potent and PI3K-alpha subtype-selective phosphoinositide 3-kinase (PI3K) inhibitor.

UPC:: 12141723
Condition:: New
HazmatClass:: No
MPN:: SML3217-25MG
CAS:: 2067281-51-8

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