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pc4, serine mutations human

PC4 SERINE MUTATIONS HUMAN

Catalog No.
C005B-306473
Manufacturer No.
SRP2024-10UG
Manufacturer Name
Sigma-Aldrich
Quantity
1
Unit of Measure
EA

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Biochem/physiol Actions Human PC4 is a non-TAF transcription coactivator that mediates activator-dependent transcription by RNA polymerase II in vitro through most tested activators. The function of PC4 is through interactions with

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Biochem/physiol Actions

Human PC4 is a non-TAF transcription coactivator that mediates activator-dependent transcription by RNA polymerase II in vitro through most tested activators. The function of PC4 is through interactions with transcriptional activators and the basal transcription machinery. It is negatively regulated by casein kinase II phosphorylation both in vitro and in vivo. PC4 strongly binds single stranded DNA and the region essential for the single stranded DNA binding activity was mapped around residue 77. A single amino acid change at position 77 (F to P) abolishes both ds- and ss-DNA binding activity.

Physical form

Clear and colorless frozen liquid solution

Preparation Note

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. While working, please keep sample on ice.

UPC:
85131504
Condition:
New
HazmatClass:
No
MPN:
SRP2024-10UG
Temperature Control Device:
Yes

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