PARAOXON-ETHYL (C005B-031480)

Application

Paraoxon-ethyl has been used as a substrate in paraoxonase (PON) activity assay. It has also been used as a lipase inhibitor to study the effects of anacetrapib on homotypic transfer from high density lipoprotein L3 (HDL3) to HDL2 in vivo.

Biochem/physiol Actions

Potent irreversible acetylcholinesterase inhibitor

Caution

air sensitive: handle under argon

Physical form

Oily liquid

Molecular Weight: 275.20. Empirical Formula: C₁₀H₁₄NO₆P. linearFormula: O₂NC₆H₄OP(O)(OC₂H₅)₂. Quality Level: 100. Assay: ≥. 90%. form: oil. color: yellow. refractive index: n20/D 1.51 (lit.). density: 1.274 . g/mL . at 25 . °C (lit.). storage temp.: 2-8°C. SMILES string: CCOP(: O)(OCC)Oc1ccc(cc1)[N+]([O-]): O. InChI: 1S/C10H14NO6P/c1-3-15-18(14,16-4-2)17-10-7-5-9(6-8-10)11(12)13/h5-8H,3-4H2,1-2H3. InChI key: WYMSBXTXOHUIGT-UHFFFAOYSA-N. Gene Information: human ... PON1(5444). Pictograms: GHS06,GHS09. Signal Word: Danger. Hazard Statements: H300 + H310 - H410. Precautionary Statements: P262 - P264 - P273 - P280 - P301 + P310 - P302 + P352 + P310. Hazard Classifications: Acute Tox. 1 Dermal - Acute Tox. 1 Oral - Aquatic Acute 1 - Aquatic Chronic 1. Storage Class Code: 6.1A - Combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials. WGK: WGK 3. Flash Point(F): Not applicable. Flash Point(C): Not applicable. Personal Protective Equipment: Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter.