PACLITAXEL UNITED STATES PHARMACOPEIA (USP) REFERENCE STANDARD

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Paclitaxel USP reference standard meant for use in specified quality tests and assays.

Also used to prepare standard and system suitability solutions for the assay and impurity analysis using the liquid chromatography method coupled to a UV detector according to the given below monographs of United States Pharmacopeia (USP):

• PaclitaxelInjection
• Paclitaxel

Biochem/physiol Actions

Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase. The microtubule damage induces apoptosis through a JNK-dependent pathway followed by a JNK-independent pathway, perhaps related to the activation of protein kinase A (PKA) or of Raf-1 kinase, resulting in phosphorylation of Bcl-2. A major metabolite via CYP2CB is 6α-hydroxypaclitaxel (6α-OHP).

Caution

Paclitaxel undergoes transesterification in methanol and hydrolyzes in aqueous solutions.

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  â€‹

Other Notes

USP issued SDS can be found here.

Sales restrictions may apply.

Molecular Weight: 853.91. Empirical Formula: C₄₇H₅₁NO₁₄. grade: pharmaceutical primary standard. API family: paclitaxel. manufacturer/tradename: USP. mp: 213 . °C (dec.) (lit.). application(s): pharmaceutical (small molecule). format: neat. storage temp.: 2-8°C. SMILES string: [H][C@@]12C[C@H](O)[C@@]3(C)C(: O)[C@H](OC(C): O)C4: C(C)[C@H](C[C@@](O)([C@@H](OC(: O)c5ccccc5)[C@]3([H])[C@@]1(CO2)OC(C): O)C4(C)C)OC(: O)[C@H](O)[C@@H](NC(: O)c6ccccc6)c7ccccc7. InChI: 1S/C47H51NO14/c1-25-31(60-43(56)36(52)35(28-16-10-7-11-17-28)48-41(54)29-18-12-8-13-19-29)23-47(57)40(61-42(55)30-20-14-9-15-21-30)38-45(6,32(51)22-33-46(38,24-58-33)62-27(3)50)39(53)37(59-26(2)49)34(25)44(47,4)5/h7-21,31-33,35-38,40,51-52,57H,22-24H2,1-6H3,(H,48,54)/t31-,32-,33+,35-,36+,37+,38-,40-,45+,46-,47+/m0/s1. InChI key: RCINICONZNJXQF-MZXODVADSA-N. Gene Information: human ... TUBA1A(7846), TUBA1B(10376), TUBA1C(84790), TUBA3C(7278), TUBA3E(112714), TUBA4A(7277), TUBB(203068), TUBB1(81027), TUBB2A(7280), TUBB2B(347733), TUBB3(10381), TUBB4A(10382), TUBB4B(10383), TUBB6(84617), TUBB8(347688). Pictograms: GHS08. Signal Word: Danger. Hazard Statements: H341 - H360FD - H372. Precautionary Statements: P202 - P260 - P264 - P280 - P308 + P313 - P405. Hazard Classifications: Muta. 2 - Repr. 1B - STOT RE 1. Storage Class Code: 6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects. WGK: WGK 3. Flash Point(F): Not applicable. Flash Point(C): Not applicable.