P53 (HUMAN RECOMBINANT) GST-TAGGED (C005B-438745)

Catalog No.: C005B-438745
Manufacturer No.: P6249-50UG
Manufacturer Name: Sigma-Aldrich
Quantity: 1
Unit of Measure: EA

General description p53 is regulated by MDM2, which acts as a negative regulator of p53 transcription by promoting its degradation by functioning as an E3 ubiquitin ligase which recognizes the N′: terminal transactivation domain.

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Description
Specifications

General description

p53 is regulated by MDM2, which acts as a negative regulator of p53 transcription by promoting its degradation by functioning as an E3 ubiquitin ligase which recognizes the N′ terminal transactivation domain.

Application

Useful for the study of postranslational modification of p53, or protein-protein interaction studies.

Biochem/physiol Actions

p53 gene is highly conserved and expressed in normal tissues. It is the most commonly mutated gene in human cancer and more then 500 gene mutations have been described in various types of malignancies, hematologic as well as solid tumors. Intact p53 function is essential for the maintenance of the non-tumorogenic phenotype of cells. Thus, p53 plays a vital role in suppressing the development of cancer.

Physical properties

GST-tagged, full-length human p53

UPC:: 51111602
Condition:: New
HazmatClass:: No
MPN:: P6249-50UG
Temperature Control Device:: Yes

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