Linsitinib is a potent, selective insulin-like growth factor-1 receptor (IGF-1R, IC50 = 35 nM) and insulin receptor (IR, IC50 = 75 nM) kinase inhibitor which works to block the autophosphorylation of IGF-1R and IR. Additionally, in vitro studies of Linsitinib have demonstrated its ability to inhibit the proliferation of multiple tumor cell lines.Linsitinib 是一种选择性的 IGF-1R 抑制剂,IC50 值为 35 nM,也适度地作用于 InsR,IC50 值为 75 nM;对 Abl,ALK,BTK,EGFR,FGFR1/2,PKA 等没有作用。.
Specifications and Purity: ≥99%
Molecular Formula: C26H23N5O
Molecular Weight: 421.51
PubChem CID: 11640390
Isomeric SMILES: CC1(CC(C1)C2=NC(=C3N2C=CN=C3N)C4=CC5=C(C=C4)C=CC(=N5)C6=CC=CC=C6)O
Related Documents: https://aladdin-for-icloud-store.oss-cn-hangzhou.aliyuncs.com/aladdinsci/pdp/sds/1/L126224-SCI_73f740da06b9020ddc591c826bd183c9.pdf
- UPC:
- 10161546
- Condition:
- New
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- L126224-10mg
- CAS:
- 867160-71-2
- Product Size:
- 10mg
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