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oridonin (nsc-250682)

Oridonin (NSC-250682)

Catalog No.
C007B-397711
Manufacturer No.
O409059-1ml
Manufacturer Name
Aladdin Scientific
Quantity
1
Unit of Measure
EA

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InformationOridonin (Isodonol, Rubescenin, NSC-250682), a diterpenoid purified from Rabdosia rubescens, is a traditional agent with antitumor, anti-bacterial and anti-inflammatory effects. Oridonin inhibitsAKT1andAKT2kinase activity with IC50 of 8.4

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InformationOridonin (Isodonol, Rubescenin, NSC-250682), a diterpenoid purified from Rabdosia rubescens, is a traditional agent with antitumor, anti-bacterial and anti-inflammatory effects. Oridonin inhibitsAKT1andAKT2kinase activity with IC50 of 8.4 μM and 8.9 μM, rIn vitroOridonin effectively inhibites the proliferation of a wide variety of cancer cells including those from prostate (LNCaP, DU145, PC3), breast (MCF-7, MDA-MB231), non-small cell lung (NSCL) (NCI-H520, NCI-H460, NCI-H1299) cancers, acute promyelocytic leukemia (NB4), and glioblastoma multiforme (U118, U138) with ED50s ranging from 1.8 to 7.5 μg/ml. The antitumor activities of Oridonin may due to its inhibitory effects on NF-kappaB and MAPKs signal pathways.In vivoLD50: Mice 35-40mg/kg.Cell Datacell lines：Concentrations：Incubation Time：Powder Purity:≥99%.

Specifications and Purity: 10mM in DMSO

Molecular Formula: C20H28O6

Molecular Weight: 364.43

UPC:
85121902
Condition:
New
HazmatClass:
No
WeightUOM:
LB
MPN:
O409059-1ml
CAS:
28957-04-2
Product Size:
1ml

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