Org 48762-0 is a selective p38α and β kinase inhibitor (EC50 = 0.1 μM for p38α). Selective for p38α/β over a panel of 48 other human kinases. Inhibits LPS-induced TNFα release from PBMCs. Also inhibits cytokine release in an LPS-induced endotoxemia model in mice. Orally bioavailable.
Specifications and Purity: ≥98%
Molecular Formula: C24H16F2N4
Molecular Weight: 398.41
PubChem CID: 24822135
Isomeric SMILES: CN1C=C2C(=C(C(=NC2=N1)C3=CC=C(C=C3)F)C4=CC=NC=C4)C5=CC=C(C=C5)F
Related Documents: https://aladdin-for-icloud-store.oss-cn-hangzhou.aliyuncs.com/aladdinsci/pdp/sds/1/O286758-SCI_1292952930d114b02a24025937a9a032.pdf
- UPC:
- 12141725
- Condition:
- New
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- O286758-100mg
- CAS:
- 755753-89-0
- Product Size:
- 100mg
akash.verma@cenmed.com
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