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onx-0914 tfa (c09-1160-573)

ONX-0914 TFA (C007B-382267)

Catalog No.
C007B-382267
Manufacturer No.
O661637-1ml
Manufacturer Name
Aladdin Scientific
Quantity
1
Unit of Measure
EA

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ONX-0914 (PR-957) TFA is a selective inhibitor of low-molecular mass polypeptide-7 (LMP7) , the chymotrypsin-like subunit of the immunoproteasome. ONX-0914 TFA blocks cytokine production and attenuates progression of experimental arthritis. ONX-0914

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ONX-0914 (PR-957) TFA is a selective inhibitor of low-molecular mass polypeptide-7 (LMP7) , the chymotrypsin-like subunit of the immunoproteasome. ONX-0914 TFA blocks cytokine production and attenuates progression of experimental arthritis. ONX-0914 TFA iIn Vitro:ONX-0914 inhibits LMP7-specific antigen presentation. ONX-0914 blocks cytokine productionby mouse splenocytes and blocks T celldifferentiation. MCE has not independently confirmed the accuracy of these methods. They are for reference only.In Vivo:ONX-0914 (2-10mg/kg; i.v,; on days 4, 6 and 8) meliorates disease in mouse arthritis. ONX-0914 (2, 6 and 10 mg per kg body weight on days 25, 27, 29, 31 and 33; i.v.) treatment also induced a rapid therapeutic response in the T and B cell–dependentBiological Activity:ONX-0914 (PR-957) TFA is a selective inhibitor of low-molecular mass polypeptide-7 (LMP7) , the chymotrypsin-like subunit of the immunoproteasome. ONX-0914 TFA blocks cytokine production and attenuates progression of experimental arthritis. ONX-0914 TFA i.

Specifications and Purity: 10mM in DMSO

Molecular Formula: C33H41F3N4O9

Molecular Weight: 694.7

UPC:
42201823
Condition:
New
HazmatClass:
No
WeightUOM:
LB
MPN:
O661637-1ml
Product Size:
1ml

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