akash.verma@cenmed.com
(732) 447-1115
ON-01910 is an inhibitor to PLK1 with IC50 of 9 nM. ON-01910 also inhibits PLK2, PDGFR, Flt1, BCR-ABL, Fyn, Src, and CDK1, with IC50 of 18–260 nM. ON-01910 shows cell killing activity against 94 different tumor cell lines with IC50 of 50–250 nM, including BT27, MCF-7, DU145, PC3, U87, A549, H187, RF1, HCT15, SW480, and KB cells. In HeLa cells, ON-01910 (100–250 nM) induces spindle abnormalities and apoptosis. ON-01910 also inhibits several multidrug resistant tumor cell lines.
Specifications and Purity: ≥98%
Molecular Formula: C21H24NO8S•Na
Molecular Weight: 473.43
PubChem CID: 23696523
Isomeric SMILES: COC1=C(C=C(C=C1)CS(=O)(=O)/C=C/C2=C(C=C(C=C2OC)OC)OC)NCC(=O)[O-].[Na+]
Related Documents: https://aladdin-for-icloud-store.oss-cn-hangzhou.aliyuncs.com/aladdinsci/pdp/sds/1/O335808-SCI_c05385b3bac9d174e951c2ccb8e18e52.pdf
- UPC:
- 41105600
- Condition:
- New
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- O335808-10mg
- CAS:
- 1225497-78-8
- Product Size:
- 10mg
- Precautionary Statement Codes:
- P264
