Oleic acid (C007B-398060)

Gene Informationhuman ... SOAT1(6646), SOAT2(8435)General DescriptionOleic acid is a mono-unsaturated omega-9 fatty acid created by dehydrogenation of stearic acid. It is then further dehydrogenated and elongated to create members of the n-9 family of fatty acids. Oleic acid is not an essential fatty acid (EFA); however, providing it to cells in culture reduces energy demand. Oleic acid mediates complete oxidation of fatty acid in sirtuin1- proliferator-activated receptor γ coactivator−1α (SIRT1-PGC-1α) signalling pathway. Oleic acid shows anti-inflammatory properties related to atherosclerosis and insulin resistant state. Oleic acid inhibits permeability in gap junctions and promotes glucose uptake in astrocytes. Oleic acid aids in neural cell proliferation by increasing glucose uptake and by protein kinase C (PKC) activation. Oleic acid is essential for axonal growth and neuronal clustering.ApplicationOleic acid has been used: in fatty acid oxidation rate experiments in myotubes and in Sirt1 enzyme assay to determine quantitatively its effect on lipid droplets by optical diffraction tomography as a fatty acid source in the medium for primary hepatocyte culture.

Specifications and Purity: BioReagent, for cell culture

Molecular Formula: C18H34O2

Molecular Weight: 282.46

EC Number: 204-007-1

PubChem CID: 445639

Isomeric SMILES: CCCCCCCC/C=C/CCCCCCCC(=O)O

Beilstein Registry Number: 1726542

Related Documents: https://ald-pub-files.oss-cn-shanghai.aliyuncs.com/aladdinsci/pdp/sds/1/O431503-SCI_ac640fd8e883ba2d5540090d913375e0.pdf