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nu7026

NU7026

Catalog No.
C005B-444647
Manufacturer No.
N1537-5MG
Manufacturer Name
Sigma-Aldrich
Quantity
5
Unit of Measure
MG

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Application NU7026 has been used: as a DNA-dependent protein kinase (DNA-PK) inhibitor, to pre-treat colon cancer cell in kinase inhibitor experiments for treating zygotes with visible pronuclei post 20 h-human chorionic gonadotropin (hCG)

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Application

NU7026 has been used:

  • as a DNA-dependent protein kinase (DNA-PK) inhibitor, to pre-treat colon cancer cell
  • in kinase inhibitor experiments for treating zygotes with visible pronuclei post 20 h-human chorionic gonadotropin (hCG)
  • to determine its influence on cytotoxicity of dibenzo[def,p]chrysene on HepG2 cells

Potent, ATP-competitive. IC50 = 0.23 μM. Selectivity over other PI3K-related kinases (IC50 = 13 μM for PI3K and >100 μM for ATM and ATR).

Biochem/physiol Actions

Cell permeable, small molecule benzochromenone inhibitor of DNA-PK (DNA dependent protein kinase).

UPC:
12141728
Condition:
New
HazmatClass:
No
MPN:
N1537-5MG
CAS:
154447-35-5
Temperature Control Device:
Yes

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