NORFLOXACIN (C005B-058148)

General description

Norfloxacin is an antimicrobial drug, belonging to the class of fluoroquinolones (FQs), which shows broad-spectrum activity against a wide range of Gram-negative and Gram-positive organisms.

Application

Norfloxacin may be used as an analytical reference standard for the determination of the analyte in pharmaceutical formulations, biological fluids and sewage using various chromatography techniques.

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Biochem/physiol Actions

Norfloxacin blocks DNA replication by interfering with an ATP-induced structural transition of DNA complexed with DNA gyrase (topoisomerase).
Mode of action: inhibits bacterial DNA replication
Antimicrobial spectrum: Gram-negative bacteria; less effective against Gram-positive bacteria

Legal Information

VETRANAL is a registered trademark of Sigma-Aldrich Chemie GmbH

Molecular Weight: 319.33. Empirical Formula: C₁₆H₁₈FN₃O₃. grade: analytical standard. Quality Level: 100. Agency: EPA 1694. product line: VETRANAL^®. . shelf life: limited shelf life, expiry date on the label. technique(s): HPLC: suitable, gas chromatography (GC): suitable. application(s): clinical testing. format: neat. storage temp.: 2-8°C. SMILES string: CCN1C: C(C(O): O)C(: O)c2cc(F)c(cc12)N3CCNCC3. InChI: 1S/C16H18FN3O3/c1-2-19-9-11(16(22)23)15(21)10-7-12(17)14(8-13(10)19)20-5-3-18-4-6-20/h7-9,18H,2-6H2,1H3,(H,22,23). InChI key: OGJPXUAPXNRGGI-UHFFFAOYSA-N. Pictograms: GHS07. Signal Word: Warning. Hazard Statements: H319. Precautionary Statements: P264 - P280 - P305 + P351 + P338 - P337 + P313. Hazard Classifications: Eye Irrit. 2. Storage Class Code: 11 - Combustible Solids. WGK: WGK 2. Personal Protective Equipment: Eyeshields, Gloves, type N95 (US).