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non endotoxin pyrogen control for use with pyromat(r) system

NEP CONTROL FLAGELLIN (C005B-447877)

Catalog No.
C005B-447877
Manufacturer No.
MATFLAGELLIN
Manufacturer Name
PyroMAT
Quantity
1
Unit of Measure
EA

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General description The PyroMAT ®: System uses cryopreserved Mono-Mac-6 (MM6) human monocytic cells as a source of monocytes. The response to a full range of pyrogens, including endotoxins and non-endotoxin pyrogens (NEPs)is determined by the

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General description

The PyroMAT® System uses cryopreserved Mono-Mac-6 (MM6) human monocytic cells as a source of monocytes. The response to a full range of pyrogens, including endotoxins and non-endotoxin pyrogens (NEPs)is determined by the measurement of interleukin-6 (IL-6) produced by the Mono-Mac-6 cells using ELISA.
NEP control flagellin is a preparation of flagellin from Salmonella typhimurium and supplied in a lyophilized form. Flagellin is a non-endotoxin pyrogen (NEP) that activates the TLR5 receptor of monocytes and can be used as a positive control with the PyroMAT® System (Monocyte Activation Test for pyrogen detection).

Specificity

TLR-5 agonist

Application

NEP control of flagellin can be used as a positive control with the PyroMAT® System. It is to be used for Product Specific Validation (PSV) and routine testing to show that the system can detect non-endotoxin pyrogen contaminants in pharmaceutical products.

Features and Benefits

Endotoxin-free product at concentration of use in MAT Purity: ≥ 95% (SDS-PAGE)

Storage and Stability

Store unopened vials at -20°C
Do not use unopened vials after expiration date
Store resuspended aliquots at -20°C
Shelf life of aliquots can be found on the technical datasheet

Legal Information

PYROMAT is a registered trademark of Merck KGaA, Darmstadt, Germany

UPC:
12163901
Condition:
New
HazmatClass:
No
MPN:
MATFLAGELLIN

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