NOCODAZOLE 1PC X 10MG (C005B-251812)

General description

Inhibitor of mitosis. Has highly specific antimicrotubular activity for mammalian cells in culture. Promotes tubulin depolymerization. Also acts as a high-affinity ligand for the cancer-related kinases ABL, c-KIT, BRAF, and MEK (K_d<2 M). The solid form of this compound (Cat. No. 487928) is also available.

Biochem/physiol Actions

Primary Target
Microtubules

Secondary Target
Certain kinases

Warning

Toxicity: Irritant (B)

Physical form

A 50 mM (10 mg/664 µL) solution of Nocodazole (Cat. No. 487928) in DMSO.

Reconstitution

Following initial thaw, aliquot and freeze (-70°C). Aliquots are stable for up to 1 year at -70°C.

Other Notes

Park, H., et al. 2012. Chem. Med. Chem.7, 53.
Bunz, F., et al. 1998. Science282, 1497.
Fleischman, L.F., et al. 1993. Oncogene8, 771.Pomies, P., and Block, M.R. 1992. Biochem. Biophys. Res. Commun.189, 1429.
Rennison, M.E., et al. 1992. J. Cell Sci.102, 239.
Thyberg, J., and Moskalewski, S. 1992. J. Cell Sci.103, 1167.

Legal Information

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