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nmdar/trpm4-in-2 free base (c09-1157-453)

NMDAR/TRPM4-IN-2 free base (C007B-379191)

Catalog No.
C007B-379191
Manufacturer No.
N654961-1ml
Manufacturer Name
Aladdin Scientific
Quantity
1
Unit of Measure
EA

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NMDAR/TRPM4-IN-2 free base (compound 8) is a potent NMDAR/TRPM4 interaction interface inhibitor. NMDAR/TRPM4-IN-2 free base shows neuroprotective activity. NMDAR/TRPM4-IN-2 free base prevents NMDA-induced cell death and mitochondrial dysfunction in

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NMDAR/TRPM4-IN-2 free base (compound 8) is a potent NMDAR/TRPM4 interaction interface inhibitor. NMDAR/TRPM4-IN-2 free base shows neuroprotective activity. NMDAR/TRPM4-IN-2 free base prevents NMDA-induced cell death and mitochondrial dysfunction in hippocampal neurons, with an IC 50 of 2.1 μM. NMDAR/TRPM4-IN-2 free base protects mice from MCAO-induced brain damage and NMDA-induced retinal ganglion cell loss.In VitroNMDAR/TRPM4-IN-2 free base (compound 8) (0-10 μM) reduces the interactions of GluN2A and GluN2B with TRPM4 in a dose-dependent manner. NMDAR/TRPM4-IN-2 free base eliminates the CREB shutoff pathway and restores ERK1/2 activation and IEG induction while sparing the synaptic activity-driven, transcription-promoting activities of NMDARs. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Specifications and Purity: 10mM in DMSO

Molecular Formula: C11H17BrN2

Molecular Weight: 257.175

UPC:
42201602
Condition:
New
HazmatClass:
No
WeightUOM:
LB
MPN:
N654961-1ml
CAS:
1353979-43-7
Product Size:
1ml

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