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niflumic acid (c15-1880-799)

NIFLUMIC ACID (C005B-444864)

Catalog No.
C005B-444864
Manufacturer No.
N0630-10G
Manufacturer Name
Sigma-Aldrich
Quantity
10
Unit of Measure
GM

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Application Niflumic acid has been used: as a chloride channel blocker in mouse olfactory epithelium for odor-induced electroolfactograms (EOGs) measurements , to test its analgesic effect on rat dorsal root ganglion neurons post

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Application

Niflumic acid has been used:

  • as a chloride channel blocker in mouse olfactory epithelium for odor-induced electroolfactograms (EOGs) measurements, to test its analgesic effect on rat dorsal root ganglion neurons post γ-aminobutyric acid induction
  • as a calcium-activated chloride channel (CaCC) inhibitor in C2C12 myoblasts and also to test its effect on volume-regulated anion channel (VRAC)
  • as an inhibitor of voltage-dependent potassium channel in human embryonic kidney (HEK 293) phoenix cells

Biochem/physiol Actions

Niflumic acid (NFA), a γ-aminobutyric acid type A receptor (GABAARs) antagonist is a non-steroidal anti-inflammatory drug (NSAID) and it belongs to the fenamate class. It is also a blocker of chloride ion channel and a calcium-activated chloride channel (CaCC) inhibitor. NFA possesses anti-inflammatory property and is useful in treating rheumatic disorders. It is also an inhibitor of N-methyl-D-aspartate receptor and glycine receptor. NFA also inhibits enzymes associated with the prostaglandins synthesis.

Selective cyclooxygenase-2 (COX-2) inhibitor.

Features and Benefits

This compound is featured on the Chloride Channels and Potassium Channels pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

UPC:
12141729
Condition:
New
HazmatClass:
Yes
MPN:
N0630-10G
CAS:
4394-00-7

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