Nevanimibe hydrochloride（PD-132301 hydrochloride）

Nevanimibe hydrochloride ( PD-132301 hydrochloride ) is a selective acyl-CoA : cholesterol O-acyltransferase 1 inhibitor with an EC50 of 9 nM. It inhibits ACAT2 with an EC50 of 368 nM. It induces apoptosis and has the potential to resist adrenocortical carcinoma. In vitro activityIn H295R human adrenocortical carcinoma cells, Nevanimibe hydrochloride(ATR-101 hydrochloride) decreases the formation of cholesteryl esters and increases FC levels, demonstrating potent inhibition of ACAT1 activity. Caspase-3/7 levels and terminal deoxynucleotidyl transferase 2'-deoxyuridine 5'-triphosphate nick end labeled-positive cells are increased by ATR-101 treatment, indicating activation of apoptosis.

Specifictaions: Moligand™, ≥98%

MDL Number: C27H40ClN3O

Molecular Formula: 458.08

PubChem CID: 131678

Isomeric SMILES: CC(C)C1=C(C(=CC=C1)C(C)C)NC(=O)NCC2(CCCC2)C3=CC=C(C=C3)N(C)C.Cl