NEOMYCIN TRISULFATE HYDRATE VETRANAL

General description

Chemical structure: aminoglycoside

Biochem/physiol Actions

Mode of action: This product acts by binding to the 30S and 50S subunits, causing miscoding and inhibiting initiation and elongation during protein synthesis. Neomycin also blocks voltage-sensitive Ca²⁺ channels without affecting the Na⁺/Ca²⁺ antiporter in neurons.

Antimicrobial spectrum: Neomycin acts against both gram-positive and gram-negative bacteria.

Legal Information

VETRANAL is a registered trademark of Sigma-Aldrich Chemie GmbH

Molecular Weight: 908.88 (anhydrous basis). Empirical Formula: C₂₃H₄₆N₆O₁₃ · 3H₂SO₄ · xH₂O. grade: analytical standard. Quality Level: 100. product line: VETRANAL^®. . shelf life: limited shelf life, expiry date on the label. technique(s): HPLC: suitable, gas chromatography (GC): suitable. application(s): clinical testing. format: neat. storage temp.: 2-8°C. SMILES string: O.OS(O)(: O): O.OS(O)(: O): O.OS(O)(: O): O.NC[C@@H]1O[C@H](O[C@H]2[C@@H](O)[C@@H](O[C@@H]2CO)O[C@@H]3[C@@H](O)[C@H](N)C[C@H](N)[C@H]3O[C@H]4O[C@H](CN)[C@@H](O)[C@H](O)[C@H]4N)C(N)[C@@H](O)[C@@H]1O. InChI: 1S/C23H46N6O13.3H2O4S.H2O/c24-2-7-13(32)15(34)10(28)21(37-7)40-18-6(27)1-5(26)12(31)20(18)42-23-17(36)19(9(4-30)39-23)41-22-11(29)16(35)14(33)8(3-25)38-22. 3*1-5(2,3)4. /h5-23,30-36H,1-4,24-29H2. 3*(H2,1,2,3,4). 1H2/t5-,6+,7-,8+,9-,10-,11?,12+,13-,14-,15-,16-,17-,18-,19-,20-,21-,22-,23+. . . . /m1..../s1. InChI key: WHAGUNPVKDUVFV-QGTTWHFQSA-N. Pictograms: GHS08. Signal Word: Danger. Hazard Statements: H317 - H334. Precautionary Statements: P261 - P272 - P280 - P284 - P302 + P352 - P304 + P340 + P312. Hazard Classifications: Resp. Sens. 1 - Skin Sens. 1. Storage Class Code: 11 - Combustible Solids. WGK: WGK 3. Flash Point(F): Not applicable. Flash Point(C): Not applicable. Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Faceshields, Gloves.