Biochem/physiol Actions
Ned-K is a specific and potent inhibitor of NAADP (nicotinic acid adenine dinucleotide phosphate) signaling that suppresses Ca2+ oscillations via two-pore channels (TPC1) and opening of the mitochondrial permeability transition pore (mPTP) in cardiomyocytes during simulated ischaemia and reperfusion. Ned-K protected cardiomyocytes from cell death during ischaemia and reperfusion injury in rats.
- UPC:
- 42261707
- Condition:
- New
- HazmatClass:
- No
- MPN:
- SML2124-5MG
akash.verma@cenmed.com
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