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n-butyldeoxynojirimycin (c15-1259-869)

N-BUTYLDEOXYNOJIRIMYCIN (C005B-058979)

Catalog No.
C005B-058979
Manufacturer No.
B8299-1MG
Manufacturer Name
Sigma-Aldrich
Quantity
1
Unit of Measure
MG

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N -Butyldeoxynojirimycin is an alkylated product of imino sugar deoxynojirimycin. Application N -Butyldeoxynojirimycin has been used: in the inhibition of glycolipid synthesis in neuroblastoma cells in the inhibition the ceramide-specific

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General description

N-Butyldeoxynojirimycin is an alkylated product of imino sugar deoxynojirimycin.

Application

N-Butyldeoxynojirimycin has been used:

  • in the inhibition of glycolipid synthesis in neuroblastoma cells
  • in the inhibition the ceramide-specific glycosyltransferase in hepatocytes
  • in the inhibition of β-glucosidase (GBA2) using fluorescence- activity assay in human embryonic kidney (HEK293) cells.

Biochem/physiol Actions

N-Butyldeoxynojirimycin is an inhibitor of glucosyltransferase and α-glucosidases. N-Butyldeoxynojirimycin, also known as misglustat, reduces glycolipid levels by substrate reduction therapy (SRT) and is effectively used for the treatment of glycosphingolipid lysosomal storage disorder, Gaucher disease.

α-glucosidase Inhibitor

Molecular Weight: 219.28. Empirical Formula: C10H21NO4. Assay: ≥. 98% (TLC). Quality Level: 200. form: film (dried in situ). solubility: water: 9.80-10.20 . mg/mL, clear, colorless. storage temp.: 2-8°C. SMILES string: CCCCN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO. InChI: 1S/C10H21NO4/c1-2-3-4-11-5-8(13)10(15)9(14)7(11)6-12/h7-10,12-15H,2-6H2,1H3/t7-,8+,9-,10-/m1/s1. InChI key: UQRORFVVSGFNRO-UTINFBMNSA-N. Gene Information: human ... UGCG(7357). Storage Class Code: 11 - Combustible Solids. WGK: WGK 3. Flash Point(F): Not applicable. Flash Point(C): Not applicable. Personal Protective Equipment: Eyeshields, Gloves, type N95 (US).
UPC:
51111704
Condition:
New
HazmatClass:
No
MPN:
B8299-1MG
CAS:
72599-27-0

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