N-Benzyl-p-Toluenesulfonamide (C007B-238371)

product description：An aryl sulphonamide that acts as a potent inhibitor of Ca2+-stimulated myosin S1 actin-stimulated ATPase activity (IC50 = ~5 µM). Also blocks actin-stimulated ATPase activity with similar potency (IC50 = 5 µM). Reversibly blocks gliding motility of skeletal muscle myosin (IC50<2 µM). Less effective in suppressing contraction in rat myocardial and rabbit slow twitch muscle compared to skeletal muscle. Does not inhibit platelet myosin II.A potent inhibitor of Ca2+-stimulated myosin S1 ATPase (IC50 = ~ 5 µM) and reversibly blocks the gliding motility. It also weakens myosin’s interaction with F-actin. Much less effective in suppressing contraction in rat myocardial or rabbit slow twitch muscle and has no effect on platelet myosin II.

Specifications and Purity: ≥98%(HPLC)

MDL Number: MFCD00159328

Molecular Formula: C14H15NO2S

Molecular Weight: 261.34

PubChem CID: 95801

Isomeric SMILES: CC1=CC=C(C=C1)S(=O)(=O)NCC2=CC=CC=C2

Beilstein Registry Number: 12(3)2328

Related Documents: https://aladdin-for-icloud-store.oss-cn-hangzhou.aliyuncs.com/aladdinsci/pdp/sds/1/N131765-SCI_31af44136cdd9aed22af69f02b6c2e16.pdf