MYELIN OLIGODENDROCYTE GLYCOPROTEIN PEPTIDE FRAGMENT 35-55 RAT MOUSE IMMUNODOMINANT EPITOPE OF MOG (C005B-454010)

Catalog No.: C005B-454010
Manufacturer No.: M4939-1MG
Manufacturer Name: Sigma-Aldrich
Quantity: 1
Unit of Measure: MG

Amino Acid Sequence Met-Glu-Val-Gly-Trp-Tyr-Arg-Ser-Pro-Phe-Ser-Arg-Val-Val-His-Leu-Tyr-Arg-Asn-Gly-Lys General description Myelin oligodendrocyte glycoprotein (MOG) is a component of the central nervous system and present on the surface of

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Description
Specifications

Amino Acid Sequence

Met-Glu-Val-Gly-Trp-Tyr-Arg-Ser-Pro-Phe-Ser-Arg-Val-Val-His-Leu-Tyr-Arg-Asn-Gly-Lys

General description

Myelin oligodendrocyte glycoprotein (MOG) is a component of the central nervous system and present on the surface of oligodendrocytes and myelin. Its extracellular domain is widely used to generate an autoimmune animal model of multiple sclerosis. In rats, it is expressed in the hippocampus.

Biochem/physiol Actions

Induces experimental autoimmune encephalomyelitis in rodents; a single injection of this peptide produces a relapsing-remitting neurologic disease with extensive plaque-like demyelination; immunization with MOG (35-55) suppresses spontaneous regeneration of dopaminergic neurons injured with MPTP.

Other Notes

Lyophilized from 0.1% TFA in H2O

UPC:: 51111805
Condition:: New
HazmatClass:: No
MPN:: M4939-1MG
CAS:: 163913-87-9

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