MUSCIMOL

General description

A constituent and psychoactive ingredient of the mushroom Amanita muscariathat acts as a potent agonist of GABA_A receptors (EC₅₀ = 28 µM and 33 µM in neonatal and adult rats, respectively), with preferential efficacy and selectivity to high-affinity receptor subtypes. Shown to be permeate the blood-brain barrier. Impairs associate and memory functions.

Biochem/physiol Actions

Primary Target
GABA_A

Warning

Toxicity: Toxic (F)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Chandra, D., et al. 2010. Neuropsychopharmacology.35, 999.
Fischer, H., et al. 2005. J. Physiol.564, 465.
Ramirez, D.R., et al. 2005. Neurobiol. Learning and Memory.84, 184.

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Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Molecular Weight: 114.10. Empirical Formula: C₄H₆N₂O₂. Assay: ≥. 99% (HPLC). Quality Level: 100. form: solid. manufacturer/tradename: Calbiochem^®. . storage condition: OK to freeze, protect from light. color: white. solubility: water: 100 . mM. storage temp.: 2-8°C. InChI: 1S/C4H6N2O2/c5-2-3-1-4(7)6-8-3/h1H,2,5H2,(H,6,7). InChI key: ZJQHPWUVQPJPQT-UHFFFAOYSA-N. Pictograms: GHS06. Signal Word: Danger. Hazard Statements: H300 - H336. Precautionary Statements: P261 - P264 - P270 - P271 - P301 + P310 - P304 + P340 + P312. Hazard Classifications: STOT SE 3. Target Organs: Central nervous system. Storage Class Code: 6.1A - Combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials. WGK: WGK 3. Flash Point(F): Not applicable. Flash Point(C): Not applicable.