Mps1-IN-3 (C007B-374196)

Mps1-IN-3 is a potent and selective MPS1 kinase inhibitor, with an IC 50 of 50 nM.In VitroMps1-IN-3 is a potent MPS1 kinase inhibitor, with an IC 50 of 50 nM. Mps1-IN-3 inhibits the proliferation of U251 glioblastoma cells with an IC 50 of appr 5 µM. Mps1-IN-3 (2 μM) can completely abrogates checkpoint. MCE has not independently confirmed the accuracy of these methods. They are for reference only.In VivoMps1-IN-3 (2 mg/kg, i.v.) sensitizes glioblastoma cells in murine tumor models, with prolonged survival and no toxicity . MCE has not independently confirmed the accuracy of these methods. They are for reference only.Form:SolidIC50& Target:Mps1 50 nM (IC 50 ).

Specifications and Purity: ≥99%

Molecular Formula: C26H31N7O4S

Molecular Weight: 537.63

PubChem CID: 91885443

Isomeric SMILES: CC(C)S(=O)(=O)C1=CC=CC=C1NC2=NC(=NC3=C2NC=N3)NC4=C(C=C(C=C4)N5CCC(CC5)O)OC