MONOCLONAL ANTI-INTERLEUKIN-18 (IL-18) RECEPTOR HUMAN CLONE 70625.111

General description

The antibody will neutralize the biological activity of recombinant human IL-18 receptor.

Immunogen

recombinant human IL-18 receptor extracellular domain, expressed in NS0 cells.

Biochem/physiol Actions

IL-18 belongs to the IL-1 cytokine superfamily and is a regulator of innate and acquired immune responses. The immune responses of IL-18 are mediated by its interaction and subsequent signaling by IL-18 receptor complex. The IL-18R complex is made up of α chain that binds to extracellular IL-18 and a β chain that is involved in signal transduction. The IL-18/IL-18R signaling enhances T and NK cell maturation, cytotoxicity and secretion of cytokines.

Physical form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline with 5% trehalose.

Preparation Note

Purified using protein G.

biological source: mouse. Quality Level: 200. conjugate: unconjugated. antibody form: purified immunoglobulin. antibody product type: primary antibodies. clone: 70625.111, monoclonal. form: lyophilized powder. species reactivity: human. technique(s): flow cytometry: suitable (2.5&. #956. g/SUP>. 10^{6 cell), immunocytochemistry: 8-25 . μ. g/mL, immunohistochemistry: 8-25 . μ. g/mL. isotype: IgG1. UniProt accession no.: Q13478. storage temp.: −. 20°C. target post-translational modification: unmodified. Gene Information: human ... IL18R1(8809). Storage Class Code: 13 - Non Combustible Solids. WGK: WGK 1. Flash Point(F): Not applicable. Flash Point(C): Not applicable.}