MMG-11 quarterhydrate

MMG-11 quarterhydrate is a potent and selective human TLR2 antagonist with low cytotoxicity. MMG-11 quarterhydrate inhibits both TLR2/1 and TLR2/6 signaling with IC 50 s of 1.7 µM for Pam 3 CSK 4 -induced hTLR2/1 and 5.7 µM for Pam 2 CSK 4 -induced hTLR2/Appearance:SolidIC50& Target:TLR2In Vitro:MMG-11 neither shows cellular toxicity nor interference with signaling induced by other TLR agonists, IL-1β or TNF. MMG-11 (0.01-100 µM) shows no cytotoxic effects up to 100 µM in peripheral blood mononuclear cells (PBMCs). MCE has not independentlyBiological Activity:MMG-11 quarterhydrate is a potent and selective human TLR2 antagonist with low cytotoxicity. MMG-11 quarterhydrate inhibits both TLR2/1 and TLR2/6 signaling with IC 50 s of 1.7u202fµM for Pam 3 CSK 4 -induced hTLR2/1 and 5.7u202fµM for Pam 2 CSK 4 -induce.

Specifications and Purity: ≥99%

Molecular Formula: C15H14O7.1/4H2O

Molecular Weight: 310.78