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mmaf-d8hydrochloride

MMAF-d8hydrochloride

Catalog No.
C007B-375610
Manufacturer No.
M658677-1mg
Manufacturer Name
Aladdin Scientific
Quantity
1
Unit of Measure
EA

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MMAF-d 8 (hydrochloride)e is a deuterated form of MMAF hydrochloride, which is a microtubule disrupting agent.Appearance:SolidIC50&: Target:AuristatinIn Vitro:MMAF shows in vitro cytotoxicity against a panel of cell lines. The IC 50 values for

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MMAF-d 8 (hydrochloride)e is a deuterated form of MMAF hydrochloride, which is a microtubule disrupting agent.Appearance:SolidIC50& Target:AuristatinIn Vitro:MMAF shows in vitro cytotoxicity against a panel of cell lines. The IC 50 values for Karpas 299, H3396, 786-O and Caki-1 are 119, 105, 257, and 200 nM, respectively. Targeted MMAF is much more potent than the free drug, and that cAC10 conjugates of MMAF dIn Vivo:The maximum tolerated dose in mice of MMAF (>16mg/kg) is much higher than MMAE (1mg/kg). cAC10-L1-MMAF 4 has an MTD of 50mg/kg in mice and 15mg/kg in rats. The corresponding cAC10-L4-MMAF 4 ADC was much less toxic, having MTDs in mice and rats of >150Biological Activity:MMAF-d 8 (hydrochloride)e is a deuterated form of MMAF hydrochloride, which is a microtubule disrupting agent.

Specifications and Purity: ≥99%

Molecular Formula: C39H58D8ClN5O8

Molecular Weight: 776.47

UPC:
12352111
Condition:
New
HazmatClass:
No
WeightUOM:
LB
MPN:
M658677-1mg
Product Size:
1mg

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