MLT-748 (C007B-231100)

Catalog No.: C007B-231100
Manufacturer No.: M414254-1mg
Manufacturer Name: Aladdin Scientific
Quantity: 1
Unit of Measure: EA

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Description
Specifications

InformationMLT-748 MLT-748 is a potent, selective and allosteric inhibitor of MALT1 with IC50 of 5 nM, binding at the interface between the caspase and immunoglobulin (Ig3) domains by displacing Trp580 and locking the catalytic site in an inactive state.TargetsMALT1 (Cell-free assay) 5 nMIn vitroMLT-748 binds MALT1 in the allosteric Trp580 pocket. MLT-748 binds and stabilizes mutant MALT1-W580S. Cleavage of MALT1 substrates is blocked by MLT-748 in B and T cells. MLT-748 rescues MALT1 function in patient MALT1mut/mut lymphocytes.Cell Research(from reference)Cell lines：Immortalized B cells, human PBMCs, primary human CD3+ T cells, primary CD4+ lymphocytes Concentrations：2 μM Incubation Time：24 h.

Specifications and Purity: ≥99%

Molecular Formula: C19H19Cl2N9O3

Molecular Weight: 492.32

PubChem CID: 129072285

UPC:: 42181504
Condition:: New
HazmatClass:: No
WeightUOM:: LB
MPN:: M414254-1mg
CAS:: 1832578-30-9
Product Size:: 1mg

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